Dr. Wolberger is a structural biologist who is on the faculty of the Johns Hopkins University School of Medicine, where she is a Professor of Biophysics and Biophysical Chemistry. Dr. Wolberger has done pioneering work on the mechanisms underlying combinatorial regulation of transcription and on ubiquitin signaling. Her current research is focused on the mechanisms by which ubiquitin plays a signaling role in transcription and in the DNA damage response.